Methyl-Sildenafil / HomoSildenafil is the research chemical variant of Sildenafil (Brand names: Viagra, Revatio, Liqrev).
Homosildenafil (also known as methyl-sildenafil) is a synthetic drug which acts as a phosphodiesterase inhibitor. It is an analog of sildenafil and vardenafil.
Homosildenafil has 35% the PDE5 inhibition activity of sildenafil itself with similar selectivity.
Sildenafil is mainly metabolized by the microsomal isozymes CYP3A4 with secondary metabolism by CYP2C9. The major active metabolite is N-desmethylsildenafil.
The plasma level of the equivalent homosildenafil metabolite reaches 40% of sildenafil's bioavailability. The N-desmethyl metabolite is further metabolized, with a half-life of 4 hours.
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